- The Polish minimalist composer Tomasz Sikorski wrote a piece of music inspired by the work, which includes a recitation of Kierkergaard's text.
- The sixteenth episode of the anime series Neon Genesis Evangelion, "The Sickness Unto Death, and Then...", is named after the book. Much of the series' philosophical and psychological subtext is influenced by, and makes reference to, the pessimism of Arthur Schopenhauer and the existentialism of Kierkegaard and Jean-Paul Sartre.
- The manga Sickness Unto Death ("Shi ni Itaru Yamai"), by Asada Hikari, uses Kierkegaard's ideas of despair within a story about multiple personality disorder.[7]
- "Sickness unto Foolish Death" is the sixth song on the original soundtrack for the video game Silent Hill 3, composed by Japanese musician Akira Yamaoka. The elements of despair, sin and death are fundamental to the Silent Hill franchise.
- The band Typhoon has a song titled "The Sickness unto Death" from the album Hunger and Thirst. The book is also referenced in the song "Caesar", from White Lighter.
- In Thomas Bernhard’s novel “Extinction”, the narrator describes having sudden urges to read ‘Sickness unto Death’, and he ultimately scoffs at himself for the thought, given his proximity and the present circumstances regarding his mother’s secret lover, who he simultaneously admires and is sickened by and is present in the same house in the days leading up to her funeral.
- Walker Percy's National Book Award winning novel The Moviegoer takes its epigraph from The Sickness Unto Death.
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